报告题目：Upconverting Fluorescent Nanoparticles for Theranostics
报告人：新加坡国立大学张勇教授
地点：曹光彪大楼326会议室
时间：2013年7月9日（星期二）上午10:00-11:30
Abstract：
Upconverting nanoparticles (UCNs) present a new technology for optical imaging/detection which is a growing field with both diagnostic and drug discovery uses. Currently, fluorophores including fluorescent dyes/proteins and quantum dots (QDs) are used for fluorescence-based imaging and detection. These are based on ‘downconversion fluorescence’, emitting low energy fluorescence when excited by high energy photons. Fluorophores in current use have several drawbacks: photobleaching, autofluorescence, short tissue penetration depth and tissue photo-damage. UCNs emit detectable photons of higher energy in the visible range upon irradiation with near-infrared (NIR) light based on a process termed ‘upconversion’. UCNs show absolute photostability, negligible autofluorescence, high penetration depth and minimum photodamage to biological tissues. They can be used for ultrasensitive interference-free biodetection because most biomolecules do not have upconversion properties. UCNs are also useful for light based therapy with enhanced efficiency, e.g., photodynamic therapy (PDT) of cancer. UCNs are used for enhanced PDT in deep tissues, because NIR light can go much deeper in tissues than visible light. They are used not only as a light converter but also a carrier for photosensitive drugs.
Biography ：
Dr. Yong Zhang: Professor in Department of Bioengineering, National University of Singapore (NUS), senior Faculty member of NUS Nanoscience & Nanotechnology Initiative and NUS Graduate School for Integrative Sciences and Engineering, Guest Professor of University of Science & Technology of China and HuangShan Chair Professor of Hefei University of Technology. He has been a research scientist in National Institute of Biomedical Engineering (Portugal), University of Washington, and PNNL/UW Joint Institute for Nanoscience. His current research interests include nanobiophotonics, nanomedicine, biomedical microdevices, and tissue engineering. He has published over 200 journal and conference papers on journals such as Nature Medicine, Nature Communications and PNAS, a number of book chapters and patents. He is in the editorial board of more than 15 peer reviewed international journals and has received research awards such as IES PrestigiousEngineering Achievement Award, NUS Young Investigator Award, and DAAD Scholarship. He has been identified by the Thomson Reuters in 2012 as a highly cited researcher.
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